3h8h: Difference between revisions

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-{{Seed}}
-[[Image:3h8h.png|left|200px]]
-<!--
+==Structure of the C-terminal domain of human RNF2/RING1B;==
-The line below this paragraph, containing "STRUCTURE_3h8h", creates the "Structure Box" on the page.
+<StructureSection load='3h8h' size='340' side='right'caption='[[3h8h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3h8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H8H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3h8h|  PDB=3h8h  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h8h OCA], [https://pdbe.org/3h8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h8h RCSB], [https://www.ebi.ac.uk/pdbsum/3h8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h8h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RING2_HUMAN RING2_HUMAN] E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity.<ref>PMID:11513855</ref> <ref>PMID:15386022</ref> <ref>PMID:16359901</ref> <ref>PMID:16714294</ref> <ref>PMID:20696397</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h8h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h8h ConSurf].
+<div style="clear:both"></div>
-===Structure of the C-terminal domain of human RNF2/RING1B;===
+==See Also==
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_19791798}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 19791798 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_19791798}}
-==About this Structure==
-H8H is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8H OCA].
-==Reference==
-<ref group="xtra">PMID:19791798</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bacik, J.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bezsonova, I.]]
+[[Category: Bacik J]]
-[[Category: Bochkarev, A.]]
+[[Category: Bezsonova I]]
-[[Category: Bountra, C.]]
+[[Category: Bochkarev A]]
-[[Category: Dhe-Paganon, S.]]
+[[Category: Bountra C]]
-[[Category: Duan, S.]]
+[[Category: Dhe-Paganon S]]
-[[Category: Edwards, A M.]]
+[[Category: Duan S]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Edwards AM]]
-[[Category: Walker, J R.]]
+[[Category: Walker JR]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Chromatin regulator]]
-[[Category: Chromosomal protein]]
-[[Category: E3-ligase]]
-[[Category: Ligase]]
-[[Category: Metal-binding]]
-[[Category: Nuclear protein]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Polycomb]]
-[[Category: Proto-oncogene]]
-[[Category: Repressor]]
-[[Category: Ring1b]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]
-[[Category: Transcription regulation complex]]
-[[Category: Ubiquitin fold]]
-[[Category: Ubl conjugation]]
-[[Category: Ubl conjugation pathway]]
-[[Category: Zinc]]
-[[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:54:24 2009''