3h4p: Difference between revisions

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[[Image:3h4p.jpg|left|200px]]


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==Proteasome 20S core particle from Methanocaldococcus jannaschii==
The line below this paragraph, containing "STRUCTURE_3h4p", creates the "Structure Box" on the page.
<StructureSection load='3h4p' size='340' side='right'caption='[[3h4p]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3h4p]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H4P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h4p OCA], [https://pdbe.org/3h4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h4p RCSB], [https://www.ebi.ac.uk/pdbsum/3h4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h4p ProSAT]</span></td></tr>
{{STRUCTURE_3h4p| PDB=3h4p |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSA_METJA PSA_METJA] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, displays caspase-like and chymotrypsin-like activities and low level of trypsin-like activity.[HAMAP-Rule:MF_00289]<ref>PMID:10692374</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/3h4p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h4p ConSurf].
<div style="clear:both"></div>


===Proteasome 20S core particle from Methanocaldococcus jannaschii===
==See Also==
 
*[[Proteasome 3D structures|Proteasome 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_19481527}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 19481527 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_19481527}}
 
==About this Structure==
3H4P is a 28 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4P OCA].
 
==Reference==
<ref group="xtra">PMID:19481527</ref><references group="xtra"/>
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Proteasome endopeptidase complex]]
[[Category: Finley D]]
[[Category: Finley, D.]]
[[Category: Hu M]]
[[Category: Hu, M.]]
[[Category: Jeffrey PD]]
[[Category: Jeffrey, P D.]]
[[Category: Shi Y]]
[[Category: Shi, Y.]]
[[Category: Tian G]]
[[Category: Tian, G.]]
[[Category: Zhang F]]
[[Category: Zhang, F.]]
[[Category: Zhang P]]
[[Category: Zhang, P.]]
[[Category: 20]]
[[Category: Core particle]]
[[Category: Cytoplasm]]
[[Category: Hydrolase]]
[[Category: Protease]]
[[Category: Proteasome]]
[[Category: Threonine protease]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 18:09:05 2009''

Latest revision as of 12:58, 21 February 2024

Proteasome 20S core particle from Methanocaldococcus jannaschiiProteasome 20S core particle from Methanocaldococcus jannaschii

Structural highlights

3h4p is a 28 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 4.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PSA_METJA Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, displays caspase-like and chymotrypsin-like activities and low level of trypsin-like activity.[HAMAP-Rule:MF_00289][1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Wilson HL, Ou MS, Aldrich HC, Maupin-Furlow J. Biochemical and physical properties of the Methanococcus jannaschii 20S proteasome and PAN, a homolog of the ATPase (Rpt) subunits of the eucaryal 26S proteasome. J Bacteriol. 2000 Mar;182(6):1680-92. PMID:10692374

3h4p, resolution 4.10Å

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