3h4m: Difference between revisions

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-{{Seed}}
-[[Image:3h4m.jpg|left|200px]]
-<!--
+==AAA ATPase domain of the proteasome- activating nucleotidase==
-The line below this paragraph, containing "STRUCTURE_3h4m", creates the "Structure Box" on the page.
+<StructureSection load='3h4m' size='340' side='right'caption='[[3h4m]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3h4m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H4M FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.106&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
-{{STRUCTURE_3h4m|  PDB=3h4m  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h4m OCA], [https://pdbe.org/3h4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h4m RCSB], [https://www.ebi.ac.uk/pdbsum/3h4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h4m ProSAT]</span></td></tr>
+</table>
-===AAA ATPase domain of the proteasome- activating nucleotidase===
+== Function ==
+[https://www.uniprot.org/uniprot/PAN_METJA PAN_METJA] ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates. In addition to ATP, is able to cleave other nucleotide triphosphates such as CTP, GTP and UTP, but hydrolysis of these other nucleotides is less effective in promoting proteolysis than ATP. Moreover, PAN by itself can function as a chaperone in vitro.[HAMAP-Rule:MF_00553]<ref>PMID:10473546</ref> <ref>PMID:10692374</ref> <ref>PMID:16337593</ref> <ref>PMID:17803938</ref> <ref>PMID:19481528</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_19481527}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 19481527 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/3h4m_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_19481527}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-H4M is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H4M OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h4m ConSurf].
+<div style="clear:both"></div>
-==Reference==
+== References ==
-<ref group="xtra">PMID:19481527</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Methanocaldococcus jannaschii]]
-[[Category: Finley, D.]]
+[[Category: Finley D]]
-[[Category: Hu, M.]]
+[[Category: Hu M]]
-[[Category: Jeffrey, P.]]
+[[Category: Jeffrey P]]
-[[Category: Shi, Y.]]
+[[Category: Shi Y]]
-[[Category: Tian, G.]]
+[[Category: Tian G]]
-[[Category: Zhang, F.]]
+[[Category: Zhang F]]
-[[Category: Zhang, P.]]
+[[Category: Zhang P]]
-[[Category: Atp-binding]]
-[[Category: Atpase]]
-[[Category: Cytoplasm]]
-[[Category: Hydrolase]]
-[[Category: Nucleotide-binding]]
-[[Category: Pan]]
-[[Category: Proteasome]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 18:09:03 2009''