3gv8: Difference between revisions

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-[[Image:3gv8.png|left|200px]]
-{{STRUCTURE_3gv8|  PDB=3gv8  |  SCENE=  }}
+==Human DNA polymerase iota in complex with T template DNA and incoming dGTP==
+<StructureSection load='3gv8' size='340' side='right'caption='[[3gv8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===Human DNA polymerase iota in complex with T template DNA and incoming dGTP===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3gv8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GV8 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19440206}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gv8 OCA], [https://pdbe.org/3gv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3gv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gv8 ProSAT]</span></td></tr>
-[[3gv8]] is a 3 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GV8 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gv8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gv8 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[DNA polymerase|DNA polymerase]]
+*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019440206</ref><references group="xtra"/>
+__TOC__
-[[Category: DNA-directed DNA polymerase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Kirouac, K N.]]
+[[Category: Large Structures]]
-[[Category: Ling, H.]]
+[[Category: Kirouac KN]]
-[[Category: Dna damage]]
+[[Category: Ling H]]
-[[Category: Dna repair]]
-[[Category: Dna replication]]
-[[Category: Dna synthesis]]
-[[Category: Dna-binding]]
-[[Category: Dna-directed dna polymerase]]
-[[Category: Error prone replication]]
-[[Category: Magnesium]]
-[[Category: Metal-binding]]
-[[Category: Mutator protein]]
-[[Category: Nucleotidyltransferase]]
-[[Category: Nucleus]]
-[[Category: Polymerase iota]]
-[[Category: Schiff base]]
-[[Category: Transferase]]
-[[Category: Transferase-dna complex]]
-[[Category: Y-family polymerase]]