3gh0: Difference between revisions

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[[Image:3gh0.png|left|200px]]


{{STRUCTURE_3gh0|  PDB=3gh0  |  SCENE=  }}
==Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability==
 
<StructureSection load='3gh0' size='340' side='right'caption='[[3gh0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
===Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3gh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GH0 FirstGlance]. <br>
{{ABSTRACT_PUBMED_20151707}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gh0 OCA], [https://pdbe.org/3gh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gh0 RCSB], [https://www.ebi.ac.uk/pdbsum/3gh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gh0 ProSAT]</span></td></tr>
[[3gh0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GH0 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/3gh0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gh0 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020151707</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Bell, B J.]]
[[Category: Bell BJ]]
[[Category: Gibson, L M.]]
[[Category: Gibson LM]]
[[Category: Huang, X.]]
[[Category: Huang X]]
[[Category: Lebioda, L.]]
[[Category: Lebioda L]]
[[Category: Lovelace, L L.]]
[[Category: Lovelace LL]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Transferase]]

Latest revision as of 12:54, 21 February 2024

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular StabilityReplacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability

Structural highlights

3gh0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.56Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_HUMAN Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108

3gh0, resolution 1.56Å

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OCA
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