3gh0: Difference between revisions

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-[[Image:3gh0.png|left|200px]]
-{{STRUCTURE_3gh0|  PDB=3gh0  |  SCENE=  }}
+==Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability==
+<StructureSection load='3gh0' size='340' side='right'caption='[[3gh0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
-===Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3gh0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GH0 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_20151707}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gh0 OCA], [https://pdbe.org/3gh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gh0 RCSB], [https://www.ebi.ac.uk/pdbsum/3gh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gh0 ProSAT]</span></td></tr>
-[[3gh0]] is a 1 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GH0 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/3gh0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gh0 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Thymidylate synthase|Thymidylate synthase]]
+*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:020151707</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Thymidylate synthase]]
+[[Category: Large Structures]]
-[[Category: Bell, B J.]]
+[[Category: Bell BJ]]
-[[Category: Gibson, L M.]]
+[[Category: Gibson LM]]
-[[Category: Huang, X.]]
+[[Category: Huang X]]
-[[Category: Lebioda, L.]]
+[[Category: Lebioda L]]
-[[Category: Lovelace, L L.]]
+[[Category: Lovelace LL]]
-[[Category: Methyltransferase]]
-[[Category: Nucleotide biosynthesis]]
-[[Category: Transferase]]