3g8c: Difference between revisions

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-[[Image:3g8c.png|left|200px]]
-{{STRUCTURE_3g8c|  PDB=3g8c  |  SCENE=  }}
+==Crystal Structure of Biotin Carboxylase in Complex with Biotin, Bicarbonate, ADP and Mg Ion==
+<StructureSection load='3g8c' size='340' side='right'caption='[[3g8c]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===Crystal Stucture of Biotin Carboxylase in Complex with Biotin, Bicarbonate, ADP and Mg Ion===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3g8c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8C FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19213731}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8c OCA], [https://pdbe.org/3g8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8c RCSB], [https://www.ebi.ac.uk/pdbsum/3g8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8c ProSAT]</span></td></tr>
-[[3g8c]] is a 2 chain structure of [[Biotin carboxylase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8C OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8c_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g8c ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Biotin carboxylase|Biotin carboxylase]]
+*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:019213731</ref><references group="xtra"/>
+[[Category: Escherichia coli K-12]]
-[[Category: Escherichia coli]]
+[[Category: Large Structures]]
-[[Category: Chou, C Y.]]
+[[Category: Chou CY]]
-[[Category: Tong, L.]]
+[[Category: Tong L]]
-[[Category: Yu, L P.]]
+[[Category: Yu LP]]
-[[Category: Atp-binding]]
-[[Category: Atp-grasp]]
-[[Category: Biotin]]
-[[Category: Biotin-dependent]]
-[[Category: Carboxylase]]
-[[Category: Fatty acid biosynthesis]]
-[[Category: Fatty acid synthesis]]
-[[Category: Ligase]]
-[[Category: Lipid synthesis]]
-[[Category: Nucleotide-binding]]
-[[Category: Substrates bound]]