3fr5: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3fr5.png|left|200px]]


<!--
==N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors==
The line below this paragraph, containing "STRUCTURE_3fr5", creates the "Structure Box" on the page.
<StructureSection load='3fr5' size='340' side='right'caption='[[3fr5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FR5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I4A:5-(3-CARBAMOYLBENZYL)-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-4-CARBOXYLIC+ACID'>I4A</scene></td></tr>
{{STRUCTURE_3fr5| PDB=3fr5 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fr5 OCA], [https://pdbe.org/3fr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fr5 RCSB], [https://www.ebi.ac.uk/pdbsum/3fr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fr5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FABP4_HUMAN FABP4_HUMAN] Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/3fr5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fr5 ConSurf].
<div style="clear:both"></div>


===N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors===
==See Also==
 
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
 
__TOC__
<!--  
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_19217286}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 19217286 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_19217286}}
 
==About this Structure==
3FR5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FR5 OCA].
 
==Reference==
<ref group="xtra">PMID:19217286</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Axen, E.]]
[[Category: Large Structures]]
[[Category: Barf, T.]]
[[Category: Axen E]]
[[Category: Haile, S.]]
[[Category: Barf T]]
[[Category: Hammer, K.]]
[[Category: Haile S]]
[[Category: Lehmann, F.]]
[[Category: Hammer K]]
[[Category: Medina, C.]]
[[Category: Lehmann F]]
[[Category: Rondahl, L.]]
[[Category: Lundb ck T]]
[[Category: Svensson, S.]]
[[Category: Medina C]]
[[Category: Uppenberg, J.]]
[[Category: Rondahl L]]
[[Category: Ck, T Lundb.]]
[[Category: Svensson S]]
[[Category: Cytoplasm]]
[[Category: Uppenberg J]]
[[Category: Lipid binding protein]]
[[Category: Lipid-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  2 16:23:07 2009''

Latest revision as of 12:50, 21 February 2024

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitorsN-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte Fatty-Acid Binding Protein (A-FABP) inhibitors

Structural highlights

3fr5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FABP4_HUMAN Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3fr5, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3fr5&oldid=4064739"