3fhb: Difference between revisions
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New page: '''Unreleased structure''' The entry 3fhb is ON HOLD Authors: Lehtio, L., Karlberg, T., Arrowsmith, C.H., Berglung, H., Busam, R., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S.... |
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==Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid== | |||
<StructureSection load='3fhb' size='340' side='right'caption='[[3fhb]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3fhb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2pa9 2pa9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhb OCA], [https://pdbe.org/3fhb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhb RCSB], [https://www.ebi.ac.uk/pdbsum/3fhb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhb ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhb_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fhb ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Berglund H]] | |||
[[Category: Busam R]] | |||
[[Category: Collins R]] | |||
[[Category: Dahlgren LG]] | |||
[[Category: Edwards AM]] | |||
[[Category: Flodin S]] | |||
[[Category: Flores A]] | |||
[[Category: Graslund S]] | |||
[[Category: Hallberg BM]] | |||
[[Category: Hammarstrom M]] | |||
[[Category: Holmberg-Schiavone L]] | |||
[[Category: Johansson I]] | |||
[[Category: Karlberg T]] | |||
[[Category: Kotenyova T]] | |||
[[Category: Lehtio L]] | |||
[[Category: Moche M]] | |||
[[Category: Nordlund P]] | |||
[[Category: Nyman T]] | |||
[[Category: Ogg D]] | |||
[[Category: Persson C]] | |||
[[Category: Sagemark J]] | |||
[[Category: Schueler H]] | |||
[[Category: Stenmark P]] | |||
[[Category: Sundstrom M]] | |||
[[Category: Thorsell AG]] | |||
[[Category: Van Den Berg S]] | |||
[[Category: Weigelt J]] | |||
Latest revision as of 12:49, 21 February 2024
Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acidHuman poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic acid
Structural highlights
FunctionPARP3_HUMAN Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Large Structures
- Arrowsmith CH
- Berglund H
- Busam R
- Collins R
- Dahlgren LG
- Edwards AM
- Flodin S
- Flores A
- Graslund S
- Hallberg BM
- Hammarstrom M
- Holmberg-Schiavone L
- Johansson I
- Karlberg T
- Kotenyova T
- Lehtio L
- Moche M
- Nordlund P
- Nyman T
- Ogg D
- Persson C
- Sagemark J
- Schueler H
- Stenmark P
- Sundstrom M
- Thorsell AG
- Van Den Berg S
- Weigelt J