3epp: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 3epp is ON HOLD
+==Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin==
+<StructureSection load='3epp' size='340' side='right'caption='[[3epp]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
-Authors: Amaya, M.F., Zeng, H., Loppnau, P., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Botchkarev, A., Min, J., Plotnikov, A.N., Wu, H., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3epp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EPP FirstGlance]. <br>
-Description: Crystal structure of mRNA cap guanine-N7 methyltransferase (RNMT) in complex with sinefungin
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene></td></tr>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  8 09:21:17 2008''
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3epp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epp OCA], [https://pdbe.org/3epp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3epp RCSB], [https://www.ebi.ac.uk/pdbsum/3epp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3epp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3epp ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Amaya MF]]
+[[Category: Arrowsmith CH]]
+[[Category: Botchkarev A]]
+[[Category: Bountra C]]
+[[Category: Edwards AM]]
+[[Category: Loppnau P]]
+[[Category: Min J]]
+[[Category: Plotnikov AN]]
+[[Category: Weigelt J]]
+[[Category: Wu H]]
+[[Category: Zeng H]]