3ed7: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:3ed7.jpg|left|200px]]
-<!--
+==Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability==
-The line below this paragraph, containing "STRUCTURE_3ed7", creates the "Structure Box" on the page.
+<StructureSection load='3ed7' size='340' side='right'caption='[[3ed7]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ed7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ED7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ED7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3ed7|  PDB=3ed7  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ed7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ed7 OCA], [https://pdbe.org/3ed7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ed7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ed7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ed7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ed/3ed7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ed7 ConSurf].
+<div style="clear:both"></div>
-===Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability===
+==See Also==
+*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_20151707}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 20151707 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_20151707}}
-==About this Structure==
-ED7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ED7 OCA].
-==Reference==
-<ref group="xtra">PMID:20151707</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Thymidylate synthase]]
+[[Category: Large Structures]]
-[[Category: Bell, B J.]]
+[[Category: Bell BJ]]
-[[Category: Berger, F G.]]
+[[Category: Berger FG]]
-[[Category: Berger, S H.]]
+[[Category: Berger SH]]
-[[Category: Gibson, L M.]]
+[[Category: Gibson LM]]
-[[Category: Huang, X.]]
+[[Category: Huang X]]
-[[Category: Lovelace, L L.]]
+[[Category: Lovelace LL]]
-[[Category: Pena, M M.]]
+[[Category: Pena MM]]
-[[Category: Methyltransferase]]
-[[Category: Nucleotide biosynthesis]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  3 15:55:51 2010''