3ebf: Difference between revisions

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-{{Seed}}
-[[Image:3ebf.png|left|200px]]
-<!--
+==Structure of inhibited murine iNOS oxygenase domain==
-The line below this paragraph, containing "STRUCTURE_3ebf", creates the "Structure Box" on the page.
+<StructureSection load='3ebf' size='340' side='right'caption='[[3ebf]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ebf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EBF FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=332:(3R)-3-[(1,2,3,4-TETRAHYDROISOQUINOLIN-7-YLOXY)METHYL]-2,3-DIHYDROTHIENO[2,3-F][1,4]OXAZEPIN-5-AMINE'>332</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3ebf|  PDB=3ebf  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ebf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ebf OCA], [https://pdbe.org/3ebf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ebf RCSB], [https://www.ebi.ac.uk/pdbsum/3ebf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ebf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/3ebf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ebf ConSurf].
+<div style="clear:both"></div>
-===Structure of inhibited murine iNOS oxygenase domain===
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18849972}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_18849972}}
-==About this Structure==
-EBF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EBF OCA].
-==Reference==
-Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase., Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED, Nat Chem Biol. 2008 Nov;4(11):700-7. Epub 2008 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18849972 18849972]
 [[Category: Mus musculus]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Aberg A]]
-[[Category: Single protein]]
+[[Category: Andersson G]]
-[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
+[[Category: Andrews G]]
-[[Category: Fad]]
+[[Category: Arvai AS]]
-[[Category: Fmn]]
+[[Category: Cheshire DR]]
-[[Category: Heme]]
+[[Category: Connolly S]]
-[[Category: Iron]]
+[[Category: Crane BR]]
-[[Category: Metal-binding]]
+[[Category: Garcin ED]]
-[[Category: Nadp]]
+[[Category: Gensmantel NP]]
-[[Category: Nitric oxide synthase]]
+[[Category: Getzoff ED]]
-[[Category: No]]
+[[Category: Hamley PJ]]
-[[Category: Oxidoreductase]]
+[[Category: Kroeger MD]]
-[[Category: Oxidoreductase calmodulin-binding]]
+[[Category: Mallinder PR]]
-[[Category: Polymorphism]]
+[[Category: Mete A]]
-[[Category: Tetrahydrobiopterin]]
+[[Category: Nicholls DJ]]
-[[Category: Zinc]]
+[[Category: Rosenfeld RJ]]
+[[Category: St-Gallay SA]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 20:13:06 2009''
+[[Category: Stuehr DJ]]
+[[Category: Tainer JA]]
+[[Category: Tinker AC]]
+[[Category: Wallace AV]]