3eb1: Difference between revisions

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-[[Image:3eb1.png|left|200px]]
-{{STRUCTURE_3eb1|  PDB=3eb1  |  SCENE=  }}
+==Crystal structure PTP1B complex with small molecule inhibitor LZP-25==
+<StructureSection load='3eb1' size='340' side='right'caption='[[3eb1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-===Crystal structure PTP1B complex with small molecule inhibitor LZP-25===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3eb1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EB1 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19012396}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZQ:4-[3-(DIBENZYLAMINO)PHENYL]-2,4-DIOXOBUTANOIC+ACID'>LZQ</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eb1 OCA], [https://pdbe.org/3eb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eb1 RCSB], [https://www.ebi.ac.uk/pdbsum/3eb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eb1 ProSAT]</span></td></tr>
-[[3eb1]] is a 1 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EB1 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/3eb1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eb1 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:019012396</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Large Structures]]
-[[Category: Gunawan, A M.]]
+[[Category: Gunawan AM]]
-[[Category: Liu, S.]]
+[[Category: Liu S]]
-[[Category: Long, Y Q.]]
+[[Category: Long Y-Q]]
-[[Category: Wu, L.]]
+[[Category: Wu L]]
-[[Category: Xue, T.]]
+[[Category: Xue T]]
-[[Category: Yu, X.]]
+[[Category: Yu X]]
-[[Category: Zhang, Z Y]]
+[[Category: Zhang Z-Y]]
-[[Category: Zheng, L F.]]
+[[Category: Zheng L-F]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Hydrolase]]
-[[Category: Inhibitor]]
-[[Category: Membrane]]
-[[Category: Oxidation]]
-[[Category: Phosphoprotein]]
-[[Category: Protein phosphatase]]
-[[Category: Protein tyrosine phosphatase]]
-[[Category: Ptp1b]]