3eah: Difference between revisions

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-{{Seed}}
-[[Image:3eah.png|left|200px]]
-<!--
+==Structure of inhibited human eNOS oxygenase domain==
-The line below this paragraph, containing "STRUCTURE_3eah", creates the "Structure Box" on the page.
+<StructureSection load='3eah' size='340' side='right'caption='[[3eah]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3eah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAH FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=327:(3S,5E)-3-PROPYL-3,4-DIHYDROTHIENO[2,3-F][1,4]OXAZEPIN-5(2H)-IMINE'>327</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3eah|  PDB=3eah  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eah OCA], [https://pdbe.org/3eah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eah RCSB], [https://www.ebi.ac.uk/pdbsum/3eah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eah ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS3_HUMAN NOS3_HUMAN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.<ref>PMID:17264164</ref>   Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.<ref>PMID:17264164</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eah_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eah ConSurf].
+<div style="clear:both"></div>
-===Structure of inhibited human eNOS oxygenase domain===
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18849972}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_18849972}}
-==About this Structure==
-EAH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAH OCA].
-==Reference==
-<ref group="xtra">PMID:18849972</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Large Structures]]
-[[Category: Aberg, A.]]
+[[Category: Aberg A]]
-[[Category: Andersson, G.]]
+[[Category: Andersson G]]
-[[Category: Andrews, G.]]
+[[Category: Andrews G]]
-[[Category: Arvai, A S.]]
+[[Category: Arvai AS]]
-[[Category: Cheshire, D R.]]
+[[Category: Cheshire DR]]
-[[Category: Connolly, S.]]
+[[Category: Connolly S]]
-[[Category: Crane, B R.]]
+[[Category: Crane BR]]
-[[Category: Garcin, E D.]]
+[[Category: Garcin ED]]
-[[Category: Gensmantel, N P.]]
+[[Category: Gensmantel NP]]
-[[Category: Getzoff, E D.]]
+[[Category: Getzoff ED]]
-[[Category: Hamley, P J.]]
+[[Category: Hamley PJ]]
-[[Category: Kroeger, M D.]]
+[[Category: Kroeger MD]]
-[[Category: Mallinder, P R.]]
+[[Category: Mallinder PR]]
-[[Category: Mete, A.]]
+[[Category: Mete A]]
-[[Category: Nicholls, D J.]]
+[[Category: Nicholls DJ]]
-[[Category: Rosenfeld, R J.]]
+[[Category: Rosenfeld RJ]]
-[[Category: St-Gallay, S A.]]
+[[Category: St-Gallay SA]]
-[[Category: Stuehr, D J.]]
+[[Category: Stuehr DJ]]
-[[Category: Tainer, J A.]]
+[[Category: Tainer JA]]
-[[Category: Tinker, A C.]]
+[[Category: Tinker AC]]
-[[Category: Wallace, A V.]]
+[[Category: Wallace AV]]
-[[Category: Fad]]
-[[Category: Fmn]]
-[[Category: Heme]]
-[[Category: Iron]]
-[[Category: Metal-binding]]
-[[Category: Nadp]]
-[[Category: Nitric oxide synthase]]
-[[Category: No]]
-[[Category: Oxidoreductase]]
-[[Category: Oxidoreductase calmodulin-binding]]
-[[Category: Polymorphism]]
-[[Category: Tetrahydrobiopterin]]
-[[Category: Zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:33:07 2009''