3ea3: Difference between revisions

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-[[Image:3ea3.png|left|200px]]
-{{STRUCTURE_3ea3|  PDB=3ea3  |  SCENE=  }}
+==Crystal Structure of the Y246S/Y247S/Y248S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis==
+<StructureSection load='3ea3' size='340' side='right'caption='[[3ea3]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ea3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EA3 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ea3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ea3 OCA], [https://pdbe.org/3ea3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ea3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ea3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ea3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PLC_BACTU PLC_BACTU] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3ea3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ea3 ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of the Y246S/Y247S/Y248S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis===
+==See Also==
+*[[Phospholipase C|Phospholipase C]]
-{{ABSTRACT_PUBMED_19369255}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[3ea3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EA3 OCA].
-==Reference==
-<ref group="xtra">PMID:019369255</ref><references group="xtra"/>
 [[Category: Bacillus thuringiensis]]
-[[Category: Phosphatidylinositol diacylglycerol-lyase]]
+[[Category: Large Structures]]
-[[Category: Head, J F.]]
+[[Category: Head JF]]
-[[Category: Redfied, A G.]]
+[[Category: Redfied AG]]
-[[Category: Roberts, M F.]]
+[[Category: Roberts MF]]
-[[Category: Seaton, B A.]]
+[[Category: Seaton BA]]
-[[Category: Shao, C.]]
+[[Category: Shao C]]
-[[Category: Shi, X.]]
+[[Category: Shi X]]
-[[Category: Zambonelli, C.]]
+[[Category: Zambonelli C]]
-[[Category: Zhang, X.]]
+[[Category: Zhang X]]
-[[Category: Dimer]]
-[[Category: Interfacially impaired]]
-[[Category: Lipid degradation]]
-[[Category: Lyase]]
-[[Category: Membrane binding]]
-[[Category: Phosphatidylinositol-specific phospholipase c]]
-[[Category: Pi-plc]]
-[[Category: Secreted]]
-[[Category: Tim barrel]]