3e7g: Difference between revisions
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New page: '''Unreleased structure''' The entry 3e7g is ON HOLD Authors: Elsa D. Garcin, Andrew S. Arvai, Robin J. Rosenfeld, Matt D. Kroeger, Brian R. Crane, Gunilla Andersson, Glen Andrews, Pete... |
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==Structure of human INOSOX with inhibitor AR-C95791== | |||
<StructureSection load='3e7g' size='340' side='right'caption='[[3e7g]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3e7g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7G FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT2:ETHYL+4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE'>AT2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7g OCA], [https://pdbe.org/3e7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7g RCSB], [https://www.ebi.ac.uk/pdbsum/3e7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7g ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7g_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7g ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Aberg A]] | |||
[[Category: Andersson G]] | |||
[[Category: Andrews G]] | |||
[[Category: Arvai AS]] | |||
[[Category: Cheshire DR]] | |||
[[Category: Connolly S]] | |||
[[Category: Crane BR]] | |||
[[Category: Garcin ED]] | |||
[[Category: Gensmantel NP]] | |||
[[Category: Getzoff ED]] | |||
[[Category: Hamley PJ]] | |||
[[Category: Kroeger MD]] | |||
[[Category: Mallinder PR]] | |||
[[Category: Mete A]] | |||
[[Category: Nicholls DJ]] | |||
[[Category: Rosenfeld RJ]] | |||
[[Category: St-Gallay SA]] | |||
[[Category: Stueh DJ]] | |||
[[Category: Tainer JA]] | |||
[[Category: Tinker AC]] | |||
[[Category: Wallace AV]] | |||
Latest revision as of 12:45, 21 February 2024
Structure of human INOSOX with inhibitor AR-C95791Structure of human INOSOX with inhibitor AR-C95791
Structural highlights
FunctionNOS2_HUMAN Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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