3e6t: Difference between revisions

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-[[Image:3e6t.png|left|200px]]
-{{STRUCTURE_3e6t|  PDB=3e6t  |  SCENE=  }}
+==Structure of murine INOS oxygenase domain with inhibitor AR-C118901==
+<StructureSection load='3e6t' size='340' side='right'caption='[[3e6t]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-===Structure of murine INOS oxygenase domain with inhibitor AR-C118901===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3e6t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E6T FirstGlance]. <br>
-{{ABSTRACT_PUBMED_18849972}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1A2:5-(4-AMINO-1-ETHYL-5,8-DIFLUORO-1H-SPIRO[PIPERIDINE-4,2-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE'>1A2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6t OCA], [https://pdbe.org/3e6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e6t RCSB], [https://www.ebi.ac.uk/pdbsum/3e6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e6t ProSAT]</span></td></tr>
-[[3e6t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e6t_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e6t ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018849972</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Aberg A]]
-[[Category: Aberg, A.]]
+[[Category: Andersson G]]
-[[Category: Andersson, G.]]
+[[Category: Andrews G]]
-[[Category: Andrews, G.]]
+[[Category: Arvai AS]]
-[[Category: Arvai, A S.]]
+[[Category: Cheshire DR]]
-[[Category: Cheshire, D R.]]
+[[Category: Connolly S]]
-[[Category: Connolly, S.]]
+[[Category: Crane BR]]
-[[Category: Crane, B R.]]
+[[Category: Garcin ED]]
-[[Category: Garcin, E D.]]
+[[Category: Gensmantel NP]]
-[[Category: Gensmantel, N P.]]
+[[Category: Getzoff ED]]
-[[Category: Getzoff, E D.]]
+[[Category: Hamley PJ]]
-[[Category: Hamley, P J.]]
+[[Category: Kroeger MD]]
-[[Category: Kroeger, M D.]]
+[[Category: Mallinder PR]]
-[[Category: Mallinder, P R.]]
+[[Category: Mete A]]
-[[Category: Mete, A.]]
+[[Category: Nicholls DJ]]
-[[Category: Nicholls, D J.]]
+[[Category: Rosenfeld RJ]]
-[[Category: Rosenfeld, R J.]]
+[[Category: St-Gallay SA]]
-[[Category: St-Gallay, S A.]]
+[[Category: Stueh DJ]]
-[[Category: Stueh, D J.]]
+[[Category: Tainer JA]]
-[[Category: Tainer, J A.]]
+[[Category: Tinker AC]]
-[[Category: Tinker, A C.]]
+[[Category: Wallace AV]]
-[[Category: Wallace, A V.]]
-[[Category: Calmodulin-binding]]
-[[Category: Fad]]
-[[Category: Fmn]]
-[[Category: Heme]]
-[[Category: Iron]]
-[[Category: Metal-binding]]
-[[Category: Nadp]]
-[[Category: Nitric oxide]]
-[[Category: No]]
-[[Category: Oxidoreductase]]
-[[Category: Tetrahydrobiopterin]]