3e6n: Difference between revisions
New page: '''Unreleased structure''' The entry 3e6n is ON HOLD Authors: Garcin, E.D., Arvai, A.S., Rosenfeld, R.J., Kroeger, M.D., Crane, B.R., Andersson, G., Andrews, G., Hamley, P.J., Mallinder... |
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==Structure of murine INOS oxygenase domain with inhibitor AR-C125813== | |||
<StructureSection load='3e6n' size='340' side='right'caption='[[3e6n]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3e6n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E6N FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AS3:4-METHYL-6-PROPYLPYRIDIN-2-AMINE'>AS3</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6n OCA], [https://pdbe.org/3e6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e6n RCSB], [https://www.ebi.ac.uk/pdbsum/3e6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e6n ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e6n_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e6n ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Aberg A]] | |||
[[Category: Andersson G]] | |||
[[Category: Andrews G]] | |||
[[Category: Arvai AS]] | |||
[[Category: Cheshire DR]] | |||
[[Category: Connolly S]] | |||
[[Category: Crane BR]] | |||
[[Category: Garcin ED]] | |||
[[Category: Gensmantel NP]] | |||
[[Category: Getzoff ED]] | |||
[[Category: Hamley PJ]] | |||
[[Category: Kroeger MD]] | |||
[[Category: Mallinder PR]] | |||
[[Category: Mete A]] | |||
[[Category: Nicholls DJ]] | |||
[[Category: Rosenfeld RJ]] | |||
[[Category: St-Gallay SA]] | |||
[[Category: Stueh DJ]] | |||
[[Category: Tainer JA]] | |||
[[Category: Tinker AC]] | |||
[[Category: Wallace AV]] | |||