3e67: Difference between revisions

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[[Image:3e67.png|left|200px]]


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==Murine inos dimer with inhibitor 4-MAP bound==
The line below this paragraph, containing "STRUCTURE_3e67", creates the "Structure Box" on the page.
<StructureSection load='3e67' size='340' side='right'caption='[[3e67]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e67]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E67 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BVF:4-METHYLPYRIDIN-2-AMINE'>BVF</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
{{STRUCTURE_3e67|  PDB=3e67  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e67 OCA], [https://pdbe.org/3e67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e67 RCSB], [https://www.ebi.ac.uk/pdbsum/3e67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e67 ProSAT]</span></td></tr>
 
</table>
===Murine inos dimer with inhibitor 4-MAP bound===
== Function ==
 
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_18849972}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e67_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[3e67]] is a 2 chain structure of [[Nitric Oxide Synthase (Part II)]] and [[Nitric oxide synthase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E67 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e67 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nitric Oxide Synthase (Part II)]]
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
*[[Nitric oxide synthase]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:018849972</ref><references group="xtra"/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Nitric-oxide synthase]]
[[Category: Aberg A]]
[[Category: Aberg, A.]]
[[Category: Andersson G]]
[[Category: Andersson, G.]]
[[Category: Andrews G]]
[[Category: Andrews, G.]]
[[Category: Arvai AS]]
[[Category: Arvai, A S.]]
[[Category: Cheshire DR]]
[[Category: Cheshire, D R.]]
[[Category: Connolly S]]
[[Category: Connolly, S.]]
[[Category: Crane BR]]
[[Category: Crane, B R.]]
[[Category: Garcin ED]]
[[Category: Garcin, E D.]]
[[Category: Gensmantel NP]]
[[Category: Gensmantel, N P.]]
[[Category: Getzoff ED]]
[[Category: Getzoff, E D.]]
[[Category: Hamley PJ]]
[[Category: Hamley, P J.]]
[[Category: Kroeger MD]]
[[Category: Kroeger, M D.]]
[[Category: Mallinder PR]]
[[Category: Mallinder, P R.]]
[[Category: Mete A]]
[[Category: Mete, A.]]
[[Category: Nicholls DJ]]
[[Category: Nicholls, D J.]]
[[Category: Rosenfeld RJ]]
[[Category: Rosenfeld, R J.]]
[[Category: St-Gallay SA]]
[[Category: St-Gallay, S A.]]
[[Category: Stueh DJ]]
[[Category: Stueh, D J.]]
[[Category: Tainer JA]]
[[Category: Tainer, J A.]]
[[Category: Tinker AC]]
[[Category: Tinker, A C.]]
[[Category: Wallace AV]]
[[Category: Wallace, A V.]]
[[Category: Calmodulin-binding]]
[[Category: Dimer]]
[[Category: Fad]]
[[Category: Fmn]]
[[Category: Heme]]
[[Category: Iron]]
[[Category: Isozyme-specific inhibitor]]
[[Category: Metal-binding]]
[[Category: Nadp]]
[[Category: Nitric oxide sythase]]
[[Category: Oxidoreductase]]
[[Category: Oxygenase domain]]

Latest revision as of 12:44, 21 February 2024

Murine inos dimer with inhibitor 4-MAP boundMurine inos dimer with inhibitor 4-MAP bound

Structural highlights

3e67 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NOS2_MOUSE Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70. PMID:16373578 doi:http://dx.doi.org/10.1126/science.1119407

3e67, resolution 2.60Å

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OCA
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