3e66: Difference between revisions

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-{{Seed}}
-[[Image:3e66.jpg|left|200px]]
-<!--
+==Crystal structure of the beta-finger domain of yeast Prp8==
-The line below this paragraph, containing "STRUCTURE_3e66", creates the "Structure Box" on the page.
+<StructureSection load='3e66' size='340' side='right'caption='[[3e66]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3e66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E66 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e66 OCA], [https://pdbe.org/3e66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e66 RCSB], [https://www.ebi.ac.uk/pdbsum/3e66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e66 ProSAT]</span></td></tr>
-{{STRUCTURE_3e66|  PDB=3e66  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e66_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e66 ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of the beta-finger domain of yeast Prp8===
+==See Also==
+*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18779563}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18779563 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_18779563}}
-==About this Structure==
-E66 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E66 OCA].
-==Reference==
-Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins., Yang K, Zhang L, Xu T, Heroux A, Zhao R, Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13817-22. Epub 2008 Sep 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18779563 18779563]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Single protein]]
+[[Category: Heroux A]]
-[[Category: Heroux, A.]]
+[[Category: Xu T]]
-[[Category: Xu, T.]]
+[[Category: Yang K]]
-[[Category: Yang, K.]]
+[[Category: Zhang L]]
-[[Category: Zhang, L.]]
+[[Category: Zhao R]]
-[[Category: Zhao, R.]]
-[[Category: Beta-finger]]
-[[Category: Mrna processing]]
-[[Category: Mrna splicing]]
-[[Category: Nucleus]]
-[[Category: Rna-binding protein]]
-[[Category: Rnase h fold]]
-[[Category: Spliceosomal protein]]
-[[Category: Spliceosome]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 15 15:56:44 2008''