3e1r: Difference between revisions

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[[Image:3e1r.png|left|200px]]


{{STRUCTURE_3e1r|  PDB=3e1r  |  SCENE=  }}
==Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55==
 
<StructureSection load='3e1r' size='340' side='right'caption='[[3e1r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3e1r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E1R FirstGlance]. <br>
{{ABSTRACT_PUBMED_18948538}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e1r OCA], [https://pdbe.org/3e1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e1r RCSB], [https://www.ebi.ac.uk/pdbsum/3e1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e1r ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3e1r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E1R OCA].  
== Function ==
[https://www.uniprot.org/uniprot/CEP55_HUMAN CEP55_HUMAN] Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.<ref>PMID:16198290</ref> <ref>PMID:17853893</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Elia, N.]]
[[Category: Large Structures]]
[[Category: Ghirlando, R.]]
[[Category: Elia N]]
[[Category: Hurley, J H.]]
[[Category: Ghirlando R]]
[[Category: Lee, H H.]]
[[Category: Hurley JH]]
[[Category: Lippincott-Schwartz, J.]]
[[Category: Lee HH]]
[[Category: Alix]]
[[Category: Lippincott-Schwartz J]]
[[Category: Apoptosis]]
[[Category: Cell cycle]]
[[Category: Cell cycle-transport protein complex]]
[[Category: Cell division]]
[[Category: Cep55]]
[[Category: Cytokinesis]]
[[Category: Escrt]]
[[Category: Host-virus interaction]]
[[Category: Mitosis]]
[[Category: Phosphoprotein]]
[[Category: Protein transport]]
[[Category: Transport]]

Latest revision as of 12:44, 21 February 2024

Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55

Structural highlights

3e1r is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CEP55_HUMAN Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.[1] [2]

References

  1. ↑ Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell. 2005 Oct;9(4):477-88. PMID:16198290 doi:S1534-5807(05)00337-0
  2. ↑ Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J. 2007 Oct 3;26(19):4215-27. Epub 2007 Sep 13. PMID:17853893 doi:10.1038/sj.emboj.7601850

3e1r, resolution 2.00Å

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