3dy8: Difference between revisions

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[[Image:3dy8.png|left|200px]]


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==Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)==
The line below this paragraph, containing "STRUCTURE_3dy8", creates the "Structure Box" on the page.
<StructureSection load='3dy8' size='340' side='right'caption='[[3dy8]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dy8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DY8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
{{STRUCTURE_3dy8| PDB=3dy8 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dy8 OCA], [https://pdbe.org/3dy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dy8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dy8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dy8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dy8 ConSurf].
<div style="clear:both"></div>


===Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
<!--
<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 18757755 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18757755}}
 
==About this Structure==
3DY8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DY8 OCA].
 
==Reference==
Structural basis for the catalytic mechanism of human phosphodiesterase 9., Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS, Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18757755 18757755]
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Danley, D.]]
[[Category: Danley D]]
[[Category: Dillman, K.]]
[[Category: Dillman K]]
[[Category: Liu, S.]]
[[Category: Liu S]]
[[Category: Mansour,M N.]]
[[Category: Mansour MN]]
[[Category: Menniti, F.]]
[[Category: Menniti F]]
[[Category: Perez, J.]]
[[Category: Perez J]]
[[Category: Alternative splicing]]
[[Category: Cgmp]]
[[Category: Enzyme mechanism]]
[[Category: Hydrolase]]
[[Category: Manganese]]
[[Category: Metal-binding]]
[[Category: Phosphodiestrase]]
[[Category: Phosphoprotein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 09:11:53 2008''

Latest revision as of 12:43, 21 February 2024

Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)

Structural highlights

3dy8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.15Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE9A_HUMAN Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13309-14. Epub 2008 Aug 29. PMID:18757755

3dy8, resolution 2.15Å

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OCA
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