3dy8: Difference between revisions

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-[[Image:3dy8.png|left|200px]]
-{{STRUCTURE_3dy8|  PDB=3dy8  |  SCENE=  }}
+==Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)==
+<StructureSection load='3dy8' size='340' side='right'caption='[[3dy8]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-===Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3dy8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DY8 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_18757755}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dy8 OCA], [https://pdbe.org/3dy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dy8 RCSB], [https://www.ebi.ac.uk/pdbsum/3dy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dy8 ProSAT]</span></td></tr>
-[[3dy8]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DY8 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dy8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dy8 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Phosphodiesterase|Phosphodiesterase]]
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018757755</ref><references group="xtra"/>
+__TOC__
-[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Danley, D.]]
+[[Category: Large Structures]]
-[[Category: Dillman, K.]]
+[[Category: Danley D]]
-[[Category: Liu, S.]]
+[[Category: Dillman K]]
-[[Category: Mansour,M N.]]
+[[Category: Liu S]]
-[[Category: Menniti, F.]]
+[[Category: Mansour MN]]
-[[Category: Perez, J.]]
+[[Category: Menniti F]]
-[[Category: Cgmp]]
+[[Category: Perez J]]
-[[Category: Enzyme mechanism]]
-[[Category: Hydrolase]]
-[[Category: Manganese]]
-[[Category: Metal-binding]]
-[[Category: Phosphodiestrase]]
-[[Category: Phosphoprotein]]