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==Structure of the catalytic subunit of telomerase, TERT==
==Structure of the catalytic subunit of telomerase, TERT==
<StructureSection load='3du6' size='340' side='right' caption='[[3du6]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='3du6' size='340' side='right'caption='[[3du6]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3du6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Red_flour_beetle Red flour beetle]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DU6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DU6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3du6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Tribolium_castaneum Tribolium castaneum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DU6 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3du5|3du5]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3du6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3du6 OCA], [http://pdbe.org/3du6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3du6 RCSB], [http://www.ebi.ac.uk/pdbsum/3du6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3du6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3du6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3du6 OCA], [https://pdbe.org/3du6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3du6 RCSB], [https://www.ebi.ac.uk/pdbsum/3du6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3du6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q0QHL8_TRICA Q0QHL8_TRICA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/3du6_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/3du6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 17: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3du6 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3du6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A common hallmark of human cancers is the overexpression of telomerase, a ribonucleoprotein complex that is responsible for maintaining the length and integrity of chromosome ends. Telomere length deregulation and telomerase activation is an early, and perhaps necessary, step in cancer cell evolution. Here we present the high-resolution structure of the Tribolium castaneum catalytic subunit of telomerase, TERT. The protein consists of three highly conserved domains, organized into a ring-like structure that shares common features with retroviral reverse transcriptases, viral RNA polymerases and B-family DNA polymerases. Domain organization places motifs implicated in substrate binding and catalysis in the interior of the ring, which can accommodate seven to eight bases of double-stranded nucleic acid. Modelling of an RNA-DNA heteroduplex in the interior of this ring demonstrates a perfect fit between the protein and the nucleic acid substrate, and positions the 3'-end of the DNA primer at the active site of the enzyme, providing evidence for the formation of an active telomerase elongation complex.
Structure of the Tribolium castaneum telomerase catalytic subunit TERT.,Gillis AJ, Schuller AP, Skordalakes E Nature. 2008 Oct 2;455(7213):633-7. Epub 2008 Aug 31. PMID:18758444<ref>PMID:18758444</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3du6" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Reverse transcriptase|Reverse transcriptase]]
*[[Telomerase|Telomerase]]
*[[Telomerase 3D structures|Telomerase 3D structures]]
*[[Telomerase 3D structures|Telomerase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Red flour beetle]]
[[Category: Large Structures]]
[[Category: Skordalakes, E]]
[[Category: Tribolium castaneum]]
[[Category: Reverse transcriptase]]
[[Category: Skordalakes E]]
[[Category: Rna-directed dna polymerase]]
[[Category: Transferase]]

Latest revision as of 12:42, 21 February 2024

Structure of the catalytic subunit of telomerase, TERTStructure of the catalytic subunit of telomerase, TERT

Structural highlights

3du6 is a 2 chain structure with sequence from Tribolium castaneum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.71Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q0QHL8_TRICA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3du6, resolution 2.71Å

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