3dsh: Difference between revisions

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{{Seed}}
[[Image:3dsh.png|left|200px]]


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==Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain==
The line below this paragraph, containing "STRUCTURE_3dsh", creates the "Structure Box" on the page.
<StructureSection load='3dsh' size='340' side='right'caption='[[3dsh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dsh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DSH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dsh OCA], [https://pdbe.org/3dsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dsh RCSB], [https://www.ebi.ac.uk/pdbsum/3dsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dsh ProSAT]</span></td></tr>
{{STRUCTURE_3dsh| PDB=3dsh |  SCENE= }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IRF5_HUMAN IRF5_HUMAN] Genetic variations in IRF5 are associated with susceptibility to inflammatory bowel disease type 14 (IBD14) [MIM:[https://omim.org/entry/612245 612245]. IBD14 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.<ref>PMID:17881657</ref>  Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10 (SLEB10) [MIM:[https://omim.org/entry/612251 612251]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.  Genetic variations in IRF5 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:[https://omim.org/entry/180300 180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
== Function ==
[https://www.uniprot.org/uniprot/IRF5_HUMAN IRF5_HUMAN] Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.<ref>PMID:11303025</ref> <ref>PMID:15695821</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/3dsh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dsh ConSurf].
<div style="clear:both"></div>


===Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain===
==See Also==
 
*[[Interferon regulatory factor|Interferon regulatory factor]]
 
== References ==
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{{ABSTRACT_PUBMED_18836453}}
 
==Disease==
Known disease associated with this structure: Inflammatory bowel disease 14, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607218 607218]], Systemic lupus erythematosus, susceptibility to, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607218 607218]]
 
==About this Structure==
3DSH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DSH OCA].
 
==Reference==
<ref group="xtra">PMID:18836453</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, W.]]
[[Category: Large Structures]]
[[Category: Correia, J J.]]
[[Category: Chen W]]
[[Category: Fitzgerald, K A.]]
[[Category: Correia JJ]]
[[Category: Jiang, Z.]]
[[Category: Fitzgerald KA]]
[[Category: Jr., W E.Royer.]]
[[Category: Jiang Z]]
[[Category: Lam, S S.]]
[[Category: Lam SS]]
[[Category: Lin, K.]]
[[Category: Lin K]]
[[Category: Schiffer, C.]]
[[Category: Royer Jr WE]]
[[Category: Srinath, H.]]
[[Category: Schiffer C]]
[[Category: Dna binding protein]]
[[Category: Srinath H]]
[[Category: Dna-binding]]
[[Category: Nucleus]]
[[Category: Phosphoactivation induced dimerization]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:56:45 2009''

Latest revision as of 12:42, 21 February 2024

Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domainCrystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain

Structural highlights

3dsh is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

IRF5_HUMAN Genetic variations in IRF5 are associated with susceptibility to inflammatory bowel disease type 14 (IBD14) [MIM:612245. IBD14 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.[1] Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10 (SLEB10) [MIM:612251. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Genetic variations in IRF5 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Function

IRF5_HUMAN Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.[2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Dideberg V, Kristjansdottir G, Milani L, Libioulle C, Sigurdsson S, Louis E, Wiman AC, Vermeire S, Rutgeerts P, Belaiche J, Franchimont D, Van Gossum A, Bours V, Syvanen AC. An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Hum Mol Genet. 2007 Dec 15;16(24):3008-16. Epub 2007 Sep 19. PMID:17881657 doi:10.1093/hmg/ddm259
  2. ↑ Barnes BJ, Moore PA, Pitha PM. Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. J Biol Chem. 2001 Jun 29;276(26):23382-90. Epub 2001 Apr 12. PMID:11303025 doi:10.1074/jbc.M101216200
  3. ↑ Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT. The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. J Biol Chem. 2005 Apr 29;280(17):17005-12. Epub 2005 Jan 28. PMID:15695821 doi:10.1074/jbc.M412584200

3dsh, resolution 2.00Å

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