3dru: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3dru.jpg|left|200px]]
-<!--
+==Crystal Structure of Gly117Phe Alpha1-Antitrypsin==
-The line below this paragraph, containing "STRUCTURE_3dru", creates the "Structure Box" on the page.
+<StructureSection load='3dru' size='340' side='right'caption='[[3dru]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3dru]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DRU FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dru OCA], [https://pdbe.org/3dru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dru RCSB], [https://www.ebi.ac.uk/pdbsum/3dru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dru ProSAT]</span></td></tr>
-{{STRUCTURE_3dru|  PDB=3dru  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:[https://omim.org/entry/613490 613490]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.<ref>PMID:1905728</ref> <ref>PMID:2390072</ref> <ref>PMID:2227940</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/A1AT_HUMAN A1AT_HUMAN] Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>   Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).[:]<ref>PMID:1906855</ref> <ref>PMID:1406456</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3dru_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dru ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of Gly117Phe Alpha1-Antitrypsin===
+==See Also==
+*[[Alpha-1-antitrypsin 3D structures|Alpha-1-antitrypsin 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_19232354}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 19232354 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_19232354}}
-==About this Structure==
-DRU is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRU OCA].
-==Reference==
-<ref group="xtra">PMID:19232354</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Barrett, T E.]]
+[[Category: Large Structures]]
-[[Category: Gooptu, B.]]
+[[Category: Barrett TE]]
-[[Category: Lomas, D A.]]
+[[Category: Gooptu B]]
-[[Category: Mallya, M.]]
+[[Category: Lomas DA]]
-[[Category: Nobeli, I.]]
+[[Category: Mallya M]]
-[[Category: Phillips, R L.]]
+[[Category: Nobeli I]]
-[[Category: Purkiss, A.]]
+[[Category: Phillips RL]]
-[[Category: Acute phase]]
+[[Category: Purkiss A]]
-[[Category: Alpha1-antitrypsin]]
-[[Category: Alternative splicing]]
-[[Category: Blood coagulation]]
-[[Category: Cirrhosis]]
-[[Category: Conformational disease]]
-[[Category: Disease mutation]]
-[[Category: Emphysema]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase inhibitor]]
-[[Category: Polymerisation]]
-[[Category: Polymorphism]]
-[[Category: Protease]]
-[[Category: Protease inhibitor]]
-[[Category: Rational drug design]]
-[[Category: Secreted]]
-[[Category: Serine protease inhibitor]]
-[[Category: Serine proteinase inhibitor]]
-[[Category: Serpin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  2 15:30:24 2009''