3d59: Difference between revisions

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-[[Image:3d59.png|left|200px]]
-{{STRUCTURE_3d59|  PDB=3d59  |  SCENE=  }}
+==Crystal structure of human plasma platelet activating factor acetylhydrolase==
+<StructureSection load='3d59' size='340' side='right'caption='[[3d59]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-===Crystal structure of human plasma platelet activating factor acetylhydrolase===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3d59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D59 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_18784071}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d59 OCA], [https://pdbe.org/3d59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d59 RCSB], [https://www.ebi.ac.uk/pdbsum/3d59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d59 ProSAT]</span></td></tr>
-[[3d59]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D59 OCA].
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PAFA_HUMAN PAFA_HUMAN] Defects in PLA2G7 are the cause of platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:[https://omim.org/entry/614278 614278]. An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. Asthmatic individuals affected by this condition may manifest severe respiratory symptoms.<ref>PMID:8675689</ref> <ref>PMID:9245731</ref> <ref>PMID:9412624</ref> <ref>PMID:9472966</ref> <ref>PMID:9759612</ref>   Defects in PLA2G7 are a cause of susceptibility to asthma (ASTHMA) [MIM:[https://omim.org/entry/600807 600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi. Note=PLA2G7 variants can be a risk factor for the development of asthma and PLA2G7 may act as a modifier gene that modulates the severity of this disease.<ref>PMID:10733466</ref>   Defects in PLA2G7 are a cause of susceptibility to atopic hypersensitivity (ATOPY) [MIM:[https://omim.org/entry/147050 147050]. A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.<ref>PMID:10733466</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PAFA_HUMAN PAFA_HUMAN] Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/3d59_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d59 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Platelet-activating factor acetylhydrolase|Platelet-activating factor acetylhydrolase]]
+*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018784071</ref><references group="xtra"/>
+__TOC__
-[[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Bahnson, B J.]]
+[[Category: Large Structures]]
-[[Category: Samanta, U.]]
+[[Category: Bahnson BJ]]
-[[Category: Alpha/beta-hydrolase-fold]]
+[[Category: Samanta U]]
-[[Category: Glycoprotein]]
-[[Category: Group viia pla2]]
-[[Category: Hydrolase]]
-[[Category: Ldl-bound]]
-[[Category: Lipid degradation]]
-[[Category: Lipoprotein associated phospholipase a2]]
-[[Category: Lp-pla2]]
-[[Category: Plasma platelet-activating factor acetylhydrolase]]
-[[Category: Secreted]]
-[[Category: Secreted protein]]