3d1m: Difference between revisions

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-[[Image:3d1m.png|left|200px]]
-{{STRUCTURE_3d1m|  PDB=3d1m  |  SCENE=  }}
+==Crystal Structure of Sonic Hedgehog Bound to the third FNIII domain of CDO==
+<StructureSection load='3d1m' size='340' side='right'caption='[[3d1m]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3d1m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D1M FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d1m OCA], [https://pdbe.org/3d1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d1m RCSB], [https://www.ebi.ac.uk/pdbsum/3d1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d1m ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d1/3d1m_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d1m ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of Sonic Hedgehog Bound to the third FNIII domain of CDO===
+==See Also==
+*[[Sonic hedgehog 3D structures|Sonic hedgehog 3D structures]]
-{{ABSTRACT_PUBMED_18794898}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[3d1m]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1M OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:018794898</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Leahy, D J.]]
+[[Category: Leahy DJ]]
-[[Category: McLellan, J S.]]
+[[Category: McLellan JS]]
-[[Category: Autocatalytic cleavage]]
-[[Category: Developmental protein]]
-[[Category: Fibronectin protein-protein complex]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Immunoglobulin domain]]
-[[Category: Lipoprotein]]
-[[Category: Membrane]]
-[[Category: Palmitate]]
-[[Category: Protease]]
-[[Category: Secreted]]
-[[Category: Signaling protein - cell adhesion complex]]
-[[Category: Transmembrane]]