3d1b: Difference between revisions

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[[Image:3d1b.png|left|200px]]


{{STRUCTURE_3d1b|  PDB=3d1b  |  SCENE=  }}
==Tetragonal crystal structure of Tas3 C-terminal alpha motif==
 
<StructureSection load='3d1b' size='340' side='right'caption='[[3d1b]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Tetragonal crystal structure of Tas3 C-terminal alpha motif===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3d1b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D1B FirstGlance]. <br>
{{ABSTRACT_PUBMED_019394293}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d1b OCA], [https://pdbe.org/3d1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d1b RCSB], [https://www.ebi.ac.uk/pdbsum/3d1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d1b ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3d1b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1B OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/TAS3_SCHPO TAS3_SCHPO] Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.<ref>PMID:15607976</ref> <ref>PMID:14704433</ref>
==Reference==
== References ==
<ref group="xtra">PMID:019394293</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Li, H.]]
[[Category: Li H]]
[[Category: Patel, D J.]]
[[Category: Patel DJ]]
[[Category: All alpha motif]]
[[Category: Cell cycle]]
[[Category: Chromosome partition]]
[[Category: Immunoglobulin fold]]
[[Category: Nuclear protein]]
[[Category: Nucleus]]
[[Category: Rits complex]]
[[Category: Rna-mediated gene silencing]]

Latest revision as of 12:39, 21 February 2024

Tetragonal crystal structure of Tas3 C-terminal alpha motifTetragonal crystal structure of Tas3 C-terminal alpha motif

Structural highlights

3d1b is a 3 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TAS3_SCHPO Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.[1] [2]

References

  1. ↑ Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell. 2004 Dec 17;119(6):789-802. PMID:15607976 doi:10.1016/j.cell.2004.11.034
  2. ↑ Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D. RNAi-mediated targeting of heterochromatin by the RITS complex. Science. 2004 Jan 30;303(5658):672-6. Epub 2004 Jan 2. PMID:14704433 doi:10.1126/science.1093686

3d1b, resolution 1.70Å

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