3cwf: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Crystal structure of PAS domain of two-component sensor histidine kinase==
==Crystal structure of PAS domain of two-component sensor histidine kinase==
<StructureSection load='3cwf' size='340' side='right' caption='[[3cwf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3cwf' size='340' side='right'caption='[[3cwf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3cwf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis Bacillus subtilis subsp. subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CWF FirstGlance]. <br>
<table><tr><td colspan='2'>[[3cwf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CWF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">phoR, BSU29100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=135461 Bacillus subtilis subsp. subtilis])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwf OCA], [https://pdbe.org/3cwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cwf RCSB], [https://www.ebi.ac.uk/pdbsum/3cwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cwf ProSAT], [https://www.topsan.org/Proteins/MCSG/3cwf TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cwf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cwf RCSB], [http://www.ebi.ac.uk/pdbsum/3cwf PDBsum], [http://www.topsan.org/Proteins/MCSG/3cwf TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PHOR_BACSU PHOR_BACSU]] Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals.  
[https://www.uniprot.org/uniprot/PHOR_BACSU PHOR_BACSU] Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We present the crystal structure of the extracytoplasmic domain of the Bacillus subtilis PhoR sensor histidine kinase, part of a two-component system involved in adaptation to low environmental phosphate concentrations. In addition to the PhoR structure, we predict that the majority of the extracytoplasmic domains of B. subtilis sensor kinases will adopt a fold similar to the ubiquitous PAS domain.
 
Extracytoplasmic PAS-like domains are common in signal transduction proteins.,Chang C, Tesar C, Gu M, Babnigg G, Joachimiak A, Pokkuluri PR, Szurmant H, Schiffer M J Bacteriol. 2010 Feb;192(4):1156-9. Epub 2009 Dec 11. PMID:20008068<ref>PMID:20008068</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Histidine kinase]]
[[Category: Large Structures]]
[[Category: Chang, C]]
[[Category: Chang C]]
[[Category: Gu, M]]
[[Category: Gu M]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Structural genomic]]
[[Category: Tesar C]]
[[Category: Tesar, C]]
[[Category: Alkaline phosphatase synthesis sensor protein phor]]
[[Category: Bacillus subtili]]
[[Category: Kinase]]
[[Category: Mcsg]]
[[Category: Membrane]]
[[Category: Pas domain]]
[[Category: Phosphate transport]]
[[Category: Phosphoprotein]]
[[Category: PSI, Protein structure initiative]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Two-component regulatory system]]

Latest revision as of 12:39, 21 February 2024

Crystal structure of PAS domain of two-component sensor histidine kinaseCrystal structure of PAS domain of two-component sensor histidine kinase

Structural highlights

3cwf is a 2 chain structure with sequence from Bacillus subtilis subsp. subtilis str. 168. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PHOR_BACSU Member of the two-component regulatory system PhoP/PhoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoP in response to environmental signals.

3cwf, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3cwf&oldid=4064092"