3cw1: Difference between revisions

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-[[Image:3cw1.png|left|200px]]
-{{STRUCTURE_3cw1|  PDB=3cw1  |  SCENE=  }}
+==Crystal Structure of Human Spliceosomal U1 snRNP==
+<StructureSection load='3cw1' size='340' side='right'caption='[[3cw1]], [[Resolution|resolution]] 5.49&Aring;' scene=''>
-===Crystal Structure of Human Spliceosomal U1 snRNP===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3cw1]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CW1 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19325628}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.493&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cw1 OCA], [https://pdbe.org/3cw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cw1 RCSB], [https://www.ebi.ac.uk/pdbsum/3cw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cw1 ProSAT]</span></td></tr>
-[[3cw1]] is a 40 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CW1 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SMD3_HUMAN SMD3_HUMAN] Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.<ref>PMID:11574479</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cw1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cw1 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Nucleoprotein|Nucleoprotein]]
+*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019325628</ref><ref group="xtra">PMID:010025403</ref><ref group="xtra">PMID:021516107</ref><ref group="xtra">PMID:015312772</ref><ref group="xtra">PMID:010931958</ref><ref group="xtra">PMID:007984237</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Krummel, D A.Pomeranz.]]
+[[Category: Large Structures]]
-[[Category: Leung, A K.]]
+[[Category: Leung AK]]
-[[Category: Li, J.]]
+[[Category: Li J]]
-[[Category: Nagai, K.]]
+[[Category: Nagai K]]
-[[Category: Oubridge, C.]]
+[[Category: Oubridge C]]
-[[Category: 5' splice site]]
+[[Category: Pomeranz Krummel DA]]
-[[Category: Pre-mrna splicing]]
-[[Category: Rna recognition motif]]
-[[Category: Rna-binding domain]]
-[[Category: Sm fold]]
-[[Category: Spliceosome]]
-[[Category: Splicing]]
-[[Category: Zinc finger]]