3cw1: Difference between revisions

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[[Image:3cw1.png|left|200px]]


{{STRUCTURE_3cw1|  PDB=3cw1  |  SCENE=  }}
==Crystal Structure of Human Spliceosomal U1 snRNP==
 
<StructureSection load='3cw1' size='340' side='right'caption='[[3cw1]], [[Resolution|resolution]] 5.49&Aring;' scene=''>
===Crystal Structure of Human Spliceosomal U1 snRNP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cw1]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CW1 FirstGlance]. <br>
{{ABSTRACT_PUBMED_19325628}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.493&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cw1 OCA], [https://pdbe.org/3cw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cw1 RCSB], [https://www.ebi.ac.uk/pdbsum/3cw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cw1 ProSAT]</span></td></tr>
[[3cw1]] is a 40 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CW1 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SMD3_HUMAN SMD3_HUMAN] Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.<ref>PMID:11574479</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/3cw1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cw1 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019325628</ref><ref group="xtra">PMID:010025403</ref><ref group="xtra">PMID:021516107</ref><ref group="xtra">PMID:015312772</ref><ref group="xtra">PMID:010931958</ref><ref group="xtra">PMID:007984237</ref><ref group="xtra">PMID:002374709</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Krummel, D A.Pomeranz.]]
[[Category: Large Structures]]
[[Category: Leung, A K.]]
[[Category: Leung AK]]
[[Category: Li, J.]]
[[Category: Li J]]
[[Category: Nagai, K.]]
[[Category: Nagai K]]
[[Category: Oubridge, C.]]
[[Category: Oubridge C]]
[[Category: 5' splice site]]
[[Category: Pomeranz Krummel DA]]
[[Category: Pre-mrna splicing]]
[[Category: Rna recognition motif]]
[[Category: Rna-binding domain]]
[[Category: Sm fold]]
[[Category: Spliceosome]]
[[Category: Splicing]]
[[Category: Zinc finger]]

Latest revision as of 12:38, 21 February 2024

Crystal Structure of Human Spliceosomal U1 snRNPCrystal Structure of Human Spliceosomal U1 snRNP

Structural highlights

3cw1 is a 40 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 5.493Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SMD3_HUMAN Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Pillai RS, Will CL, Luhrmann R, Schumperli D, Muller B. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. EMBO J. 2001 Oct 1;20(19):5470-9. PMID:11574479 doi:10.1093/emboj/20.19.5470

3cw1, resolution 5.49Å

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