3crh: Difference between revisions

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[[Image:3crh.png|left|200px]]


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==Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala==
The line below this paragraph, containing "STRUCTURE_3crh", creates the "Structure Box" on the page.
<StructureSection load='3crh' size='340' side='right'caption='[[3crh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3crh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3crh| PDB=3crh |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3crh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3crh OCA], [https://pdbe.org/3crh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3crh RCSB], [https://www.ebi.ac.uk/pdbsum/3crh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3crh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/3crh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3crh ConSurf].
<div style="clear:both"></div>


===Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala===
==See Also==
 
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_19923735}}
 
==About this Structure==
3CRH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRH OCA].
 
==Reference==
<ref group="xtra">PMID:19923735</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Blaber, M.]]
[[Category: Large Structures]]
[[Category: Honjo, E.]]
[[Category: Blaber M]]
[[Category: Kuroki, R.]]
[[Category: Honjo E]]
[[Category: Lee, J.]]
[[Category: Kuroki R]]
[[Category: Meher, A K.]]
[[Category: Lee J]]
[[Category: Somasundaram, T.]]
[[Category: Meher AK]]
[[Category: Acetylation]]
[[Category: Somasundaram T]]
[[Category: Angiogenesis]]
[[Category: Crystal packing]]
[[Category: Developmental protein]]
[[Category: Differentiation]]
[[Category: Growth factor]]
[[Category: Heparin-binding]]
[[Category: Hormone]]
[[Category: Mitogen]]
[[Category: Polymorphism]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan  6 09:03:49 2010''

Latest revision as of 12:37, 21 February 2024

Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101AlaCrystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala

Structural highlights

3crh is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.15Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FGF1_HUMAN Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7. PMID:8663044
  2. ↑ Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700. Epub 2006 Apr 4. PMID:16597617 doi:10.1074/jbc.M601252200
  3. ↑ Fernandez IS, Cuevas P, Angulo J, Lopez-Navajas P, Canales-Mayordomo A, Gonzalez-Corrochano R, Lozano RM, Valverde S, Jimenez-Barbero J, Romero A, Gimenez-Gallego G. Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J Biol Chem. 2010 Apr 9;285(15):11714-29. Epub 2010 Feb 9. PMID:20145243 doi:10.1074/jbc.M109.064618

3crh, resolution 2.15Å

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