3cln: Difference between revisions

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-{{Seed}}
-[[Image:3cln.png|left|200px]]
-<!--
+==STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION==
-The line below this paragraph, containing "STRUCTURE_3cln", creates the "Structure Box" on the page.
+<StructureSection load='3cln' size='340' side='right'caption='[[3cln]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3cln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cln 1cln]. The August 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Calmodulin''  by Shuchismita Dutta and David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_8 10.2210/rcsb_pdb/mom_2003_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CLN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-{{STRUCTURE_3cln|  PDB=3cln  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cln OCA], [https://pdbe.org/3cln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cln RCSB], [https://www.ebi.ac.uk/pdbsum/3cln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cln ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cln_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cln ConSurf].
+<div style="clear:both"></div>
-===STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION===
+==See Also==
+*[[Calmodulin 3D structures|Calmodulin 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_3145979}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 3145979 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_3145979}}
-==About this Structure==
-CLN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cln 1cln]. Additional information on 3CLN is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb44_1.html Calmodulin] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CLN OCA].
-==Reference==
-Structure of calmodulin refined at 2.2 A resolution., Babu YS, Bugg CE, Cook WJ, J Mol Biol. 1988 Nov 5;204(1):191-204. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3145979 3145979]
 [[Category: Calmodulin]]
+[[Category: Large Structures]]
+[[Category: RCSB PDB Molecule of the Month]]
 [[Category: Rattus rattus]]
-[[Category: Single protein]]
+[[Category: Babu YS]]
-[[Category: Babu, Y S.]]
+[[Category: Bugg CE]]
-[[Category: Bugg, C E.]]
+[[Category: Cook WJ]]
-[[Category: Cook, W J.]]
-[[Category: Calcium binding protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:12:53 2008''