3cl1: Difference between revisions

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[[Image:3cl1.png|left|200px]]


{{STRUCTURE_3cl1| PDB=3cl1 | SCENE= }}
==M. loti cyclic-nucleotide binding domain, cyclic-GMP bound==
<StructureSection load='3cl1' size='340' side='right'caption='[[3cl1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3cl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl1 OCA], [https://pdbe.org/3cl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl1 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CNGK1_RHILO CNGK1_RHILO] Cyclic nucleotide-regulated potassium channel activated by cAMP.<ref>PMID:15550244</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cl1 ConSurf].
<div style="clear:both"></div>


===M. loti cyclic-nucleotide binding domain, cyclic-GMP bound===
==See Also==
 
*[[Ion channels 3D structures|Ion channels 3D structures]]
{{ABSTRACT_PUBMED_18619611}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3cl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL1 OCA].
</StructureSection>
 
[[Category: Large Structures]]
==Reference==
<ref group="xtra">PMID:018619611</ref><references group="xtra"/>
[[Category: Mesorhizobium loti]]
[[Category: Mesorhizobium loti]]
[[Category: Alteiri, S L.]]
[[Category: Alteiri SL]]
[[Category: Clayton, G M.]]
[[Category: Clayton GM]]
[[Category: Morais-Cabral, J H.]]
[[Category: Morais-Cabral JH]]
[[Category: Thomas, L R.]]
[[Category: Thomas LR]]
[[Category: Cyclic-nucleotide binding]]
[[Category: Membrane protein]]

Latest revision as of 12:36, 21 February 2024

M. loti cyclic-nucleotide binding domain, cyclic-GMP boundM. loti cyclic-nucleotide binding domain, cyclic-GMP bound

Structural highlights

3cl1 is a 2 chain structure with sequence from Mesorhizobium loti. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CNGK1_RHILO Cyclic nucleotide-regulated potassium channel activated by cAMP.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Clayton GM, Silverman WR, Heginbotham L, Morais-Cabral JH. Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel. Cell. 2004 Nov 24;119(5):615-27. PMID:15550244 doi:10.1016/j.cell.2004.10.030

3cl1, resolution 2.40Å

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OCA
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