3ch8: Difference between revisions

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[[Image:3ch8.png|left|200px]]


{{STRUCTURE_3ch8|  PDB=3ch8  |  SCENE=  }}
==The crystal structure of PDZ-Fibronectin fusion protein==
 
<StructureSection load='3ch8' size='340' side='right'caption='[[3ch8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===The crystal structure of PDZ-Fibronectin fusion protein===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ch8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CH8 FirstGlance]. <br>
{{ABSTRACT_PUBMED_19646997}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch8 OCA], [https://pdbe.org/3ch8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ch8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ch8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch8 ProSAT]</span></td></tr>
[[3ch8]] is a 2 chain structure of [[Fibronectin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH8 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ERBIN_HUMAN ERBIN_HUMAN] Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).<ref>PMID:10878805</ref> <ref>PMID:16203728</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3ch8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ch8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Fibronectin|Fibronectin]]
*[[Fibronectin 3D structures|Fibronectin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019646997</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Huang, J.]]
[[Category: Large Structures]]
[[Category: Koide, A.]]
[[Category: Huang J]]
[[Category: Koide, S.]]
[[Category: Koide A]]
[[Category: Makabe, K.]]
[[Category: Koide S]]
[[Category: Fibronectin]]
[[Category: Makabe K]]
[[Category: Pdz]]
[[Category: Structural protein]]

Latest revision as of 12:35, 21 February 2024

The crystal structure of PDZ-Fibronectin fusion proteinThe crystal structure of PDZ-Fibronectin fusion protein

Structural highlights

3ch8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ERBIN_HUMAN Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adelaide J, Margolis B, Birnbaum D. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol. 2000 Jul;2(7):407-14. PMID:10878805 doi:10.1038/35017038
  2. ↑ McDonald C, Chen FF, Ollendorff V, Ogura Y, Marchetto S, Lecine P, Borg JP, Nunez G. A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem. 2005 Dec 2;280(48):40301-9. doi: 10.1074/jbc.M508538200. Epub 2005, Oct 3. PMID:16203728 doi:http://dx.doi.org/10.1074/jbc.M508538200

3ch8, resolution 1.90Å

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