3cd0: Difference between revisions
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==Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors== | |||
<StructureSection load='3cd0' size='340' side='right'caption='[[3cd0]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3cd0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CD0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6HI:(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC+ACID'>6HI</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cd0 OCA], [https://pdbe.org/3cd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cd0 RCSB], [https://www.ebi.ac.uk/pdbsum/3cd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cd0 ProSAT]</span></td></tr> | ||
[[3cd0]] is a 4 chain structure | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cd0_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cd0 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[HMG-CoA Reductase|HMG-CoA Reductase]] | *[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Finzel BC]] | ||
[[Category: | [[Category: Harris MS]] | ||
[[Category: | [[Category: Pavlovsky A]] | ||
[[Category: | [[Category: Sarver RW]] | ||
Latest revision as of 12:34, 21 February 2024
Thermodynamic and structure guided design of statin hmg-coa reductase inhibitorsThermodynamic and structure guided design of statin hmg-coa reductase inhibitors
Structural highlights
FunctionHMDH_HUMAN Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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