3ccz: Difference between revisions

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-[[Image:3ccz.png|left|200px]]
-<!--
+==Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors==
-The line below this paragraph, containing "STRUCTURE_3ccz", creates the "Structure Box" on the page.
+<StructureSection load='3ccz' size='340' side='right'caption='[[3ccz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ccz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CCZ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5HI:(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC+ACID'>5HI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3ccz|  PDB=3ccz  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ccz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccz OCA], [https://pdbe.org/3ccz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ccz RCSB], [https://www.ebi.ac.uk/pdbsum/3ccz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ccz ProSAT]</span></td></tr>
+</table>
-===Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors===
+== Function ==
+[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_18540668}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 18540668 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3ccz_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_18540668}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[3ccz]] is a 4 chain structure of [[HMG-CoA Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCZ OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ccz ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[HMG-CoA Reductase|HMG-CoA Reductase]]
+*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:018540668</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Finzel, B C.]]
+[[Category: Large Structures]]
-[[Category: Harris, M S.]]
+[[Category: Finzel BC]]
-[[Category: Pavlovsky, A.]]
+[[Category: Harris MS]]
-[[Category: Sarver, R W.]]
+[[Category: Pavlovsky A]]
-[[Category: Cholesterol biosynthesis]]
+[[Category: Sarver RW]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Glycoprotein]]
-[[Category: Hmg-coa]]
-[[Category: Lipid synthesis]]
-[[Category: Membrane]]
-[[Category: Nadph]]
-[[Category: Oxidoreductase]]
-[[Category: Peroxisome]]
-[[Category: Statin]]
-[[Category: Steroid biosynthesis]]
-[[Category: Transmembrane]]