3ccw: Difference between revisions

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[[Image:3ccw.png|left|200px]]


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==Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors==
The line below this paragraph, containing "STRUCTURE_3ccw", creates the "Structure Box" on the page.
<StructureSection load='3ccw' size='340' side='right'caption='[[3ccw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ccw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CCW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HI:(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC+ACID'>4HI</scene></td></tr>
{{STRUCTURE_3ccw|  PDB=3ccw  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ccw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ccw OCA], [https://pdbe.org/3ccw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ccw RCSB], [https://www.ebi.ac.uk/pdbsum/3ccw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ccw ProSAT]</span></td></tr>
 
</table>
===Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors===
== Function ==
 
[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_18540668}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3ccw_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_18540668}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[3ccw]] is a 4 chain structure of [[HMG-CoA Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCW OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ccw ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[HMG-CoA Reductase|HMG-CoA Reductase]]
*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018540668</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Finzel, B C.]]
[[Category: Large Structures]]
[[Category: Harris, M S.]]
[[Category: Finzel BC]]
[[Category: Pavlovsky, A.]]
[[Category: Harris MS]]
[[Category: Sarver, R W.]]
[[Category: Pavlovsky A]]
[[Category: Cholesterol biosynthesis]]
[[Category: Sarver RW]]
[[Category: Endoplasmic reticulum]]
[[Category: Glycoprotein]]
[[Category: Hmg-coa]]
[[Category: Lipid synthesis]]
[[Category: Membrane]]
[[Category: Nadph]]
[[Category: Oxidoreductase]]
[[Category: Peroxisome]]
[[Category: Statin]]
[[Category: Steroid biosynthesis]]
[[Category: Transmembrane]]

Latest revision as of 12:34, 21 February 2024

Thermodynamic and structure guided design of statin hmg-coa reductase inhibitorsThermodynamic and structure guided design of statin hmg-coa reductase inhibitors

Structural highlights

3ccw is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HMDH_HUMAN Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ccw, resolution 2.10Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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