3c66: Difference between revisions

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[[Image:3c66.png|left|200px]]


{{STRUCTURE_3c66|  PDB=3c66  |  SCENE=  }}
==Yeast poly(A) polymerase in complex with Fip1 residues 80-105==
 
<StructureSection load='3c66' size='340' side='right'caption='[[3c66]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
===Yeast poly(A) polymerase in complex with Fip1 residues 80-105===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3c66]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C66 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18537269}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c66 OCA], [https://pdbe.org/3c66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c66 RCSB], [https://www.ebi.ac.uk/pdbsum/3c66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c66 ProSAT]</span></td></tr>
[[3c66]] is a 4 chain structure of [[Poly(A) Polymerase]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C66 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAP_YEAST PAP_YEAST] Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.<ref>PMID:17850751</ref> <ref>PMID:18537269</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/3c66_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c66 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Poly(A) Polymerase|Poly(A) Polymerase]]
*[[Poly(A) polymerase 3D structures|Poly(A) polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018537269</ref><references group="xtra"/>
__TOC__
[[Category: Polynucleotide adenylyltransferase]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Bohm, A.]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Meinke, G.]]
[[Category: Bohm A]]
[[Category: Mrna processing]]
[[Category: Meinke G]]
[[Category: Nucleus]]
[[Category: Peptide-protein complex]]
[[Category: Phosphoprotein]]
[[Category: Rna-binding]]
[[Category: Transferase]]

Latest revision as of 12:33, 21 February 2024

Yeast poly(A) polymerase in complex with Fip1 residues 80-105Yeast poly(A) polymerase in complex with Fip1 residues 80-105

Structural highlights

3c66 is a 4 chain structure with sequence from Saccharomyces cerevisiae and Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PAP_YEAST Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Balbo PB, Bohm A. Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis. Structure. 2007 Sep;15(9):1117-31. PMID:17850751 doi:S0969-2126(07)00283-3
  2. ↑ Meinke G, Ezeokonkwo C, Balbo P, Stafford W, Moore C, Bohm A. Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein. Biochemistry. 2008 Jul 1;47(26):6859-69. Epub 2008 Jun 7. PMID:18537269 doi:10.1021/bi800204k

3c66, resolution 2.60Å

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