3by8: Difference between revisions

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-{{Seed}}
-[[Image:3by8.png|left|200px]]
-<!--
+==Crystal Structure of the E.coli DcuS Sensor Domain==
-The line below this paragraph, containing "STRUCTURE_3by8", creates the "Structure Box" on the page.
+<StructureSection load='3by8' size='340' side='right'caption='[[3by8]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3by8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Two-component Systems''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_10 10.2210/rcsb_pdb/mom_2015_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BY8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
-{{STRUCTURE_3by8|  PDB=3by8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3by8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3by8 OCA], [https://pdbe.org/3by8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3by8 RCSB], [https://www.ebi.ac.uk/pdbsum/3by8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3by8 ProSAT]</span></td></tr>
+</table>
-===Crystal Structure of the E.coli DcuS Sensor Domain===
+== Function ==
+[https://www.uniprot.org/uniprot/DCUS_ECOLI DCUS_ECOLI] Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation.
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_18701447}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 18701447 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/3by8_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_18701447}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-BY8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BY8 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3by8 ConSurf].
+<div style="clear:both"></div>
-==Reference==
+__TOC__
-Crystal structures of C4-dicarboxylate ligand complexes with sensor domains of histidine kinases DcuS and DctB., Cheung J, Hendrickson WA, J Biol Chem. 2008 Aug 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18701447 18701447]
+</StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Histidine kinase]]
+[[Category: Large Structures]]
-[[Category: Cheung, J.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Hendrickson, W A.]]
+[[Category: Two-component Systems]]
-[[Category: Histidine kinase sensor domain]]
+[[Category: Cheung J]]
-[[Category: Inner membrane]]
+[[Category: Hendrickson WA]]
-[[Category: Membrane]]
-[[Category: Phosphoprotein]]
-[[Category: Transferase]]
-[[Category: Transmembrane]]
-[[Category: Two-component regulatory system]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 12 09:58:04 2008''