3by8: Difference between revisions

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[[Image:3by8.png|left|200px]]


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==Crystal Structure of the E.coli DcuS Sensor Domain==
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<StructureSection load='3by8' size='340' side='right'caption='[[3by8]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3by8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Two-component Systems''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_10 10.2210/rcsb_pdb/mom_2015_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BY8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
{{STRUCTURE_3by8|  PDB=3by8  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3by8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3by8 OCA], [https://pdbe.org/3by8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3by8 RCSB], [https://www.ebi.ac.uk/pdbsum/3by8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3by8 ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of the E.coli DcuS Sensor Domain===
== Function ==
 
[https://www.uniprot.org/uniprot/DCUS_ECOLI DCUS_ECOLI] Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation.
 
== Evolutionary Conservation ==
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==About this Structure==
  </jmolCheckbox>
3BY8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BY8 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3by8 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Crystal structures of C4-dicarboxylate ligand complexes with sensor domains of histidine kinases DcuS and DctB., Cheung J, Hendrickson WA, J Biol Chem. 2008 Aug 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18701447 18701447]
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Histidine kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Cheung, J.]]
[[Category: Two-component Systems]]
[[Category: Hendrickson, W A.]]
[[Category: Cheung J]]
[[Category: Histidine kinase sensor domain]]
[[Category: Hendrickson WA]]
[[Category: Inner membrane]]
[[Category: Membrane]]
[[Category: Phosphoprotein]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Two-component regulatory system]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 27 20:20:21 2008''

Latest revision as of 12:31, 21 February 2024

Crystal Structure of the E.coli DcuS Sensor DomainCrystal Structure of the E.coli DcuS Sensor Domain

Structural highlights

3by8 is a 1 chain structure with sequence from Escherichia coli. The October 2015 RCSB PDB Molecule of the Month feature on Two-component Systems by David Goodsell is 10.2210/rcsb_pdb/mom_2015_10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.45Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCUS_ECOLI Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3by8, resolution 1.45Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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