3by8: Difference between revisions

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[[Image:3by8.png|left|200px]]


{{STRUCTURE_3by8|  PDB=3by8  |  SCENE=  }}
==Crystal Structure of the E.coli DcuS Sensor Domain==
 
<StructureSection load='3by8' size='340' side='right'caption='[[3by8]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
===Crystal Structure of the E.coli DcuS Sensor Domain===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3by8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The October 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Two-component Systems''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_10 10.2210/rcsb_pdb/mom_2015_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BY8 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18701447}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3by8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3by8 OCA], [https://pdbe.org/3by8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3by8 RCSB], [https://www.ebi.ac.uk/pdbsum/3by8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3by8 ProSAT]</span></td></tr>
[[3by8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BY8 OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/DCUS_ECOLI DCUS_ECOLI] Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation.
<ref group="xtra">PMID:018701447</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/3by8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3by8 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Histidine kinase]]
[[Category: Large Structures]]
[[Category: Cheung, J.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Hendrickson, W A.]]
[[Category: Two-component Systems]]
[[Category: Histidine kinase sensor domain]]
[[Category: Cheung J]]
[[Category: Inner membrane]]
[[Category: Hendrickson WA]]
[[Category: Membrane]]
[[Category: Phosphoprotein]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Two-component regulatory system]]

Latest revision as of 12:31, 21 February 2024

Crystal Structure of the E.coli DcuS Sensor DomainCrystal Structure of the E.coli DcuS Sensor Domain

Structural highlights

3by8 is a 1 chain structure with sequence from Escherichia coli. The October 2015 RCSB PDB Molecule of the Month feature on Two-component Systems by David Goodsell is 10.2210/rcsb_pdb/mom_2015_10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.45Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCUS_ECOLI Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3by8, resolution 1.45Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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