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<StructureSection load='3bvp' size='340' side='right'caption='[[3bvp]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3bvp' size='340' side='right'caption='[[3bvp]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3bvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_phage_tp901-1 Lactococcus phage tp901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BVP FirstGlance]. <br>
<table><tr><td colspan='2'>[[3bvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_phage_TP901-1 Lactococcus phage TP901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BVP FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">int ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35345 Lactococcus phage TP901-1])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bvp OCA], [https://pdbe.org/3bvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bvp RCSB], [https://www.ebi.ac.uk/pdbsum/3bvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bvp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bvp OCA], [https://pdbe.org/3bvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bvp RCSB], [https://www.ebi.ac.uk/pdbsum/3bvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bvp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q38184_9CAUD Q38184_9CAUD]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bvp ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bvp ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The serine integrases have recently emerged as powerful new chromosome engineering tools in various organisms and show promise for therapeutic use in human cells. The serine integrases are structurally and mechanistically unrelated to the bacteriophage lambda integrase but share a similar catalytic domain with the resolvase/invertase enzymes typified by the resolvase proteins from transposons Tn3 and gammadelta. Here we report the crystal structure and solution properties of the catalytic domain from bacteriophage TP901-1 integrase. The protein is a dimer in solution but crystallizes as a tetramer that is closely related in overall architecture to structures of activated gammadelta-resolvase mutants. The ability of the integrase tetramer to explain biochemical experiments performed in the resolvase and invertase systems suggests that the TP901 integrase tetramer represents a unique intermediate on the recombination pathway that is shared within the serine recombinase superfamily.
Tetrameric structure of a serine integrase catalytic domain.,Yuan P, Gupta K, Van Duyne GD Structure. 2008 Aug 6;16(8):1275-86. PMID:18682229<ref>PMID:18682229</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3bvp" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lactococcus phage tp901-1]]
[[Category: Lactococcus phage TP901-1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Duyne, G D.Van]]
[[Category: Van Duyne GD]]
[[Category: Yuan, P]]
[[Category: Yuan P]]
[[Category: Dna recombinase]]
[[Category: Recombination]]

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