3bo3: Difference between revisions

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-[[Image:3bo3.png|left|200px]]
-<!--
+==A relaxed active site following exon ligation by a group I intron==
-The line below this paragraph, containing "STRUCTURE_3bo3", creates the "Structure Box" on the page.
+<StructureSection load='3bo3' size='340' side='right'caption='[[3bo3]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3bo3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BO3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-{{STRUCTURE_3bo3|  PDB=3bo3  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bo3 OCA], [https://pdbe.org/3bo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bo3 RCSB], [https://www.ebi.ac.uk/pdbsum/3bo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bo3 ProSAT]</span></td></tr>
+</table>
-===A relaxed active site following exon ligation by a group I intron===
+== Function ==
+[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_18408159}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 18408159 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/3bo3_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_18408159}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[3bo3]] is a 4 chain structure of [[Kink-turn motif]], [[Nucleoprotein]], [[Ribozyme]] and [[User:Wayne Decatur/kink-turn motif]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BO3 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bo3 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Group I intron|Group I intron]]
 *[[Kink-turn motif|Kink-turn motif]]
-*[[Nucleoprotein|Nucleoprotein]]
+*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
-*[[Ribozyme|Ribozyme]]
+*[[Ribozyme 3D structures|Ribozyme 3D structures]]
 *[[User:Wayne Decatur/kink-turn motif|User:Wayne Decatur/kink-turn motif]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018408159</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Lipchock, S V.]]
+[[Category: Large Structures]]
-[[Category: Strobel, S A.]]
+[[Category: Synthetic construct]]
-[[Category: Azoarcus]]
+[[Category: Lipchock SV]]
-[[Category: Group i intron]]
+[[Category: Strobel SA]]
-[[Category: Ligation]]
-[[Category: Mrna processing]]
-[[Category: Mrna splicing]]
-[[Category: Nuclear protein-rna complex]]
-[[Category: Nucleus]]
-[[Category: Ribonucleoprotein]]
-[[Category: Ribozyme]]
-[[Category: Rna-binding]]
-[[Category: Spliceosome]]