3bac: Difference between revisions

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-[[Image:3bac.png|left|200px]]
-{{STRUCTURE_3bac|  PDB=3bac  |  SCENE=  }}
+==Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase==
+<StructureSection load='3bac' size='340' side='right'caption='[[3bac]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-===Structural Basis for the Inhibition of Bacterial NAD+ Dependent DNA Ligase===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3bac]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BAC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3B9:N-[2-(2,4-DIAMINOPYRIDO[2,3-D]PYRIMIDIN-7-YL)-2-METHYLPROPYL]-4-PHENOXYBENZAMIDE'>3B9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[3bac]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BAC OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bac OCA], [https://pdbe.org/3bac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bac RCSB], [https://www.ebi.ac.uk/pdbsum/3bac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bac ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/3bac_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bac ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[DNA ligase|DNA ligase]]
+*[[DNA ligase 3D structures|DNA ligase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Haemophilus influenzae]]
-[[Category: Pinko, C.]]
+[[Category: Large Structures]]
-[[Category: Adenylation domain]]
+[[Category: Pinko C]]
-[[Category: Dna damage]]
-[[Category: Dna repair]]
-[[Category: Dna replication]]
-[[Category: Ligase]]
-[[Category: Nad]]