2xat: Difference between revisions

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[[Image:2xat.png|left|200px]]


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==COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A==
The line below this paragraph, containing "STRUCTURE_2xat", creates the "Structure Box" on the page.
<StructureSection load='2xat' size='340' side='right'caption='[[2xat]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2xat]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLM:CHLORAMPHENICOL'>CLM</scene>, <scene name='pdbligand=DCA:DESULFO-COENZYME+A'>DCA</scene></td></tr>
{{STRUCTURE_2xat|  PDB=2xat  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xat OCA], [https://pdbe.org/2xat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xat RCSB], [https://www.ebi.ac.uk/pdbsum/2xat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xat ProSAT]</span></td></tr>
 
</table>
===COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A===
== Function ==
 
[https://www.uniprot.org/uniprot/CAT4_PSEAE CAT4_PSEAE] This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.
 
== Evolutionary Conservation ==
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{{ABSTRACT_PUBMED_9578552}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2XAT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAT OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xat ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
Structure of the hexapeptide xenobiotic acetyltransferase from Pseudomonas aeruginosa., Beaman TW, Sugantino M, Roderick SL, Biochemistry. 1998 May 12;37(19):6689-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9578552 9578552]
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Beaman TW]]
[[Category: Beaman, T W.]]
[[Category: Roderick SL]]
[[Category: Roderick, S L.]]
[[Category: Sugantino M]]
[[Category: Sugantino, M.]]
[[Category: Acetyltransferase]]
[[Category: Chloramphenicol]]
[[Category: Left-handed beta helix]]
[[Category: Xenobiotic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:01:01 2008''

Latest revision as of 12:24, 21 February 2024

COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME ACOMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A

Structural highlights

2xat is a 1 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAT4_PSEAE This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2xat, resolution 3.20Å

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