2xat: Difference between revisions

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-[[Image:2xat.png|left|200px]]
-{{STRUCTURE_2xat|  PDB=2xat  |  SCENE=  }}
+==COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A==
+<StructureSection load='2xat' size='340' side='right'caption='[[2xat]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-===COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2xat]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAT FirstGlance]. <br>
-{{ABSTRACT_PUBMED_9578552}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLM:CHLORAMPHENICOL'>CLM</scene>, <scene name='pdbligand=DCA:DESULFO-COENZYME+A'>DCA</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xat OCA], [https://pdbe.org/2xat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xat RCSB], [https://www.ebi.ac.uk/pdbsum/2xat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xat ProSAT]</span></td></tr>
-[[2xat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAT OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/CAT4_PSEAE CAT4_PSEAE] This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.
-<ref group="xtra">PMID:009578552</ref><ref group="xtra">PMID:011880627</ref><references group="xtra"/>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/2xat_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xat ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Pseudomonas aeruginosa]]
-[[Category: Beaman, T W.]]
+[[Category: Beaman TW]]
-[[Category: Roderick, S L.]]
+[[Category: Roderick SL]]
-[[Category: Sugantino, M.]]
+[[Category: Sugantino M]]
-[[Category: Acetyltransferase]]
-[[Category: Chloramphenicol]]
-[[Category: Left-handed beta helix]]
-[[Category: Xenobiotic]]