2spc: Difference between revisions

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-[[Image:2spc.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN==
-The line below this paragraph, containing "STRUCTURE_2spc", creates the "Structure Box" on the page.
+<StructureSection load='2spc' size='340' side='right'caption='[[2spc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2spc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SPC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2spc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2spc OCA], [https://pdbe.org/2spc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2spc RCSB], [https://www.ebi.ac.uk/pdbsum/2spc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2spc ProSAT]</span></td></tr>
-{{STRUCTURE_2spc|  PDB=2spc  |  SCENE=  }}
+</table>
+== Function ==
-===CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN===
+[https://www.uniprot.org/uniprot/SPTCA_DROME SPTCA_DROME] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization.<ref>PMID:8276898</ref> <ref>PMID:3680372</ref> <ref>PMID:11076973</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_8266097}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 8266097 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/2spc_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_8266097}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2spc ConSurf].
-[[2spc]] is a 2 chain structure of [[Spectrin]] with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SPC OCA].
+<div style="clear:both"></div>
 ==See Also==
-*[[Spectrin]]
+*[[Spectrin 3D structures|Spectrin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:008266097</ref><ref group="xtra">PMID:011742118</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Drosophila melanogaster]]
-[[Category: Branton, D.]]
+[[Category: Large Structures]]
-[[Category: Cronin, T.]]
+[[Category: Branton D]]
-[[Category: Harrison, S C.]]
+[[Category: Cronin T]]
-[[Category: Viel, A.]]
+[[Category: Harrison SC]]
-[[Category: Winograd, E.]]
+[[Category: Viel A]]
-[[Category: Yan, Y.]]
+[[Category: Winograd E]]
-[[Category: Cytoskeleton]]
+[[Category: Yan Y]]