2rk8: Difference between revisions

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[[Image:2rk8.png|left|200px]]


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==The Structure of rat cytosolic PEPCK in complex with phosphonoformate==
The line below this paragraph, containing "STRUCTURE_2rk8", creates the "Structure Box" on the page.
<StructureSection load='2rk8' size='340' side='right'caption='[[2rk8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rk8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RK8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PPF:PHOSPHONOFORMIC+ACID'>PPF</scene></td></tr>
{{STRUCTURE_2rk8| PDB=2rk8 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rk8 OCA], [https://pdbe.org/2rk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rk8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rk8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PCKGC_RAT PCKGC_RAT] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rk/2rk8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rk8 ConSurf].
<div style="clear:both"></div>


===The Structure of rat cytosolic PEPCK in complex with phosphonoformate===
==See Also==
 
*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
 
__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_18197707}}
 
==About this Structure==
2RK8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RK8 OCA].
 
==Reference==
<ref group="xtra">PMID:18197707</ref><references group="xtra"/>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Carlson, G M.]]
[[Category: Carlson GM]]
[[Category: Holyoak, T.]]
[[Category: Holyoak T]]
[[Category: Stiffin, R M.]]
[[Category: Stiffin RM]]
[[Category: Sullivan, S M.]]
[[Category: Sullivan SM]]
[[Category: Cytoplasm]]
[[Category: Decarboxylase]]
[[Category: Gluconeogenesis]]
[[Category: Gtp-binding]]
[[Category: Kinase]]
[[Category: Lyase]]
[[Category: Nucleotide-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:49:39 2009''

Latest revision as of 12:22, 21 February 2024

The Structure of rat cytosolic PEPCK in complex with phosphonoformateThe Structure of rat cytosolic PEPCK in complex with phosphonoformate

Structural highlights

2rk8 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PCKGC_RAT Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rk8, resolution 2.00Å

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